Dibekacin Meiji Eye Drops

Dibekacin sulfate.

Dibekacin is an aminoglycoside antibiotic.
Dibekacin sulfate occurs as a white to yellowish-white, odorless powder with a slightly bitter taste. It is very soluble in water, but practically insoluble in organic solvents eg, ethanol and acetone. Dibekacin sulfate is very stable. When it is dissolved in physiological saline solution or water for injection and kept at 25°C for 7 days, no loss of potency is observed. Dibekacin sulfate has a molecular formula of C₁₈H₃₇N₅O₈·xH₂SO₄ (x) and a molecular weight of 451.54 (free base).

Dibekacin Meiji Eye Drops has potent bactericidal activity against gram-positive and -negative bacteria including Pseudomonas aeruginosa, Proteus sp, Klebsiella pneumoniae and multi-resistant strains of Escherichia coli and Staphylococci.
Therapeutic effect of Dibekacin Meiji Eye Drops has been confirmed in a large scale of clinical trials. Dibekacin Meiji Eye Drops has the following characteristics: Bactericidal in its action against both gram-positive and gram-negative bacteria; produces therapeutic effect against infections caused by Pseudomonas aeruginosa and Proteus sp; also effective against infections due to Escherichia coli, Klebsiella pneumoniae and Staphylococci that have acquired multi-resistance to other drugs; rapidly absorbed into the blood and diffuses into the kidney and lung in high concentration after administration. It is excreted into the urine in active, unchanged form in high concentration.
Microbiology: Dibekacin exhibits strong antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and Proteus sp and against gram-positive bacteria as well. The MIC of Dibekacin Meiji Eye Drops against major pathogenic organisms is given as follows: See table.


Click on icon to see table/diagram/image

Corneal ulcers, tarsal gland infection, hordeolum (styes), blepharitis, dacryocystitis, conjunctivitis, keratitis, episcleritis.

Instill 2 drops into the affected eye 4 times daily.

Hypersensitivity to dibekacin sulfate.

Superinfection may occur.

Discontinue if irritation or sensitization occurs.

Eye Anti-Infectives & Antiseptics

J01GB09 - dibekacin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.

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